Expression of IL-2, TNF and IGF in thermochemotherapy on lung cancer
尉继伟, 石柱, 宫文宇, 刘建国
Abstract
尉继伟, 石柱, 宫文宇, 刘建国
Abstract
目的 探讨热疗联合化疗治疗非小细胞肺癌(NSCLC)对白细胞介素-2(IL-2)、肿瘤坏死因子(TNF)、胰岛素样生长因子(IGF)的影响.方法 回顾性分析2003年9月至2006年10月收治的67例NSCLC,进行微波热疗、NP方案化疗联合治疗,同时监测血清中IL-2、TNF、IGF的变化.结果 IL-2热化疗组与对照组治疗前分别为(3.68±0.49)ng/ml、(3.32±0.42)ng/ml;治疗后1个月(10.40±1.71)ng/ml、(4.41±0.48)ng/ml.TNF热化疗组、对照组治疗前(2.21±0.36)ng/ml、(2.21±0.19)ng/ml;治疗后1个月(7.83±0.55)ng/ml、(3.68±0.60)ng/ml.IGF热化疗组、对照组治疗前(79.40±3.84)ng/ml、(78.91±3.18)ng/ml;治疗后1个月(36.51±2.11)ng/ml、(52.22±3.18)ng/ml.热化疗组患者的近期疗效明显好于对照组.结论 热化疗对IL-2、TNF有明显的增高作用,而对IGF有降低作用;热化疗治疗肿瘤疗效肯定。
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目的 探讨热疗联合化疗治疗非小细胞肺癌(NSCLC)对白细胞介素-2(IL-2)、肿瘤坏死因子(TNF)、胰岛素样生长因子(IGF)的影响.方法 回顾性分析2003年9月至2006年10月收治的67例NSCLC,进行微波热疗、NP方案化疗联合治疗,同时监测血清中IL-2、TNF、IGF的变化.结果 IL-2热化疗组与对照组治疗前分别为(3.68±0.49)ng/ml、(3.32±0.42)ng/ml;治疗后1个月(10.40±1.71)ng/ml、(4.41±0.48)ng/ml.TNF热化疗组、对照组治疗前(2.21±0.36)ng/ml、(2.21±0.19)ng/ml;治疗后1个月(7.83±0.55)ng/ml、(3.68±0.60)ng/ml.IGF热化疗组、对照组治疗前(79.40±3.84)ng/ml、(78.91±3.18)ng/ml;治疗后1个月(36.51±2.11)ng/ml、(52.22±3.18)ng/ml.热化疗组患者的近期疗效明显好于对照组.结论 热化疗对IL-2、TNF有明显的增高作用,而对IGF有降低作用;热化疗治疗肿瘤疗效肯定。
Key concepts: Lung cancer, Medicine, Tumor necrosis factor alpha, Cancer research, Lung, Cancer, Immunology, Oncology