The preemptive analgesia observation of buprenorphine hydrochloride for the lower uterine segment cesarean section

Objective To observe the effect of preemptive analgesia with epidural buprenorphine on the postoperative pain for patients who were undergoing cesarean section.Methods Eighty ASA Ⅰ-Ⅱ patients underwent selective cesarean section under combined spinal epidural analgesia were randomly divided into two groups:preemptive analgesia group (group A,n =40) and control group (group B,n =40).Ten minutes before operation,the patients in group A received epidural injection of buprenorphine 0.15 mg and group B received normal saline 4 ml.The analgesia effect was assessed by visual analogue scale (VAS) at 4,8,12,24,48 hours after operation,side effects and effective pressing times of PCEA were also recorded.Results The VAS scores of group A were significantly lower than those of group B at 4,8 and 12 hours after operation(P ＜0.05).The incidence of side effects in the two groups was not significant(P ＞0.05).Conclusions Preemptive analgesia with epidural buprenorphine can provide satisfactory pain relief with no obvious side effects after lower uterine segment cesarean section. Key words: Buprenorphine;  Preemptive analgesia;  Lower uterine cesarean section