Effect of radioiodine-131 on TRAb, TSH and prognosis in hyperthyroidism

Objective To investigate the effect of radioiodine-131 on serum thyrotropin receptor antibody (TRAb), thyroid stimulating hormone (TSH) and the incidence of hypothyroidism of Graves hyperthyroidism. Methods From July 2013 to December 2015, 120 cases of hyperthyroidism in nuclear medicine were retrospectively analyzed, the serum thyroid hormone and TRAb levels before and after treatment, and the influencing factors of TSH in patients with hypothyroidism were analyzed. Results After treatment, the levels of TT3, TT4, TRAb, FT3, FT4 significantly decreased than those before treatment (P<0.05), the levels of TSH, TGAb, TPOAb significantly increased than those before treatment (P<0.05). After 6 months of treatment, hypothyroidism occurred in 44 patients(36.67%), the TSH level after treatment was selected as the dependent variable, the levels of TT3, TT4, TRAb, FT3, FT4, TGAb, TPOAb as independent variables, the results showed that, TSH was negatively correlated with TT3, TT4, TRAb, FT3, FT4 after treatment in patients with hypothyroidism (P<0.05), and TSH was positively correlated with TGAb, TPOAb (P<0.05). Conclusions The effect of Radioiodine-131 on Graves disease hyperthyroidism patients is remarkable, but to alert hypothyroidism. Key words: Radioiodine-131; Graves disease; Hyperthyroidism; Thyroid stimulating hormone receptor antibody; Thyroid stimulating hormone