Clinical significance of Pre-S1 antigen, HBV DNA, HBeAg in the detection of hepatitis B virus

Objective To study the associations among Pre-S1 antigen(Pre-S1), HBV DNA and HBeAg and explore the significance of HBV Pre-S1, HBV DNA, HBeAg detection in the viral replication. Method Pre-S1, serum markers of HBV and HBV DNA concentrations of 198 sere of hepatitis B patients were de,ted by ELISA and FQ-PCR. Results The positive rates of Pre-S1, HBV DNA and HBeAg were 54.0% (107/198), 56.1% (111/198) and 45.5%(90/198) respectively among 198 patients . The same positive rates of them were 36.4%(72/198). In 90 patients with HBeAg positive, the positive rates of Pre-S1 and HBV DNA were 80% (72/90) ,82.2% (74/171) respectively,the coincidence rates of them were great ( P > 0.05). In 108 patients with HBeAg negative, the positive rates of Pre-S1 and HBV DNA were 32.4% (35/108),34.2% (37/108) respectively. There was no significant difference in positive rate between Pre-S1 and HBV DNA( χ2 = 0.08, P > 0.05). Conclusions Pre-S1 and HBV DNA can reflect the replication of HBV sensitively, especially for those who are HBeAg negative, and can be used as a helpful tool for the diagnosis of HBV infection and clinical evaluation. Key words: Hepatitis B;  Pre-S1 antigen;  Virus;  Replication