2009•中国医师杂志Requires access
The expression and clinical significance of cox-2 in osteosarcoma and giant cell tumor of bone
Jianjun Huang, Ying Shi, Xiang Zhi-gang, Zhiliang Tian, Jiashun Luo
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Abstract
Objective To investigate the expression of cox-2 in 37 cases of osteosarcoma and 54 cases of giant cell tumor of bone,and analyze its significance in diagnosis and prognosis of osteosarcoma and giant cell tumor of bone.Methods lmmunohistochemical strain was used to detect the expression of cox-2 in 37 cases of osteosarcoma and 54 cases of giant cell tumor of bone.Results 29 cafes of giant cell tumor of bone were cox-2 positive,the expression of cox-2 was related to the recurrence.32 cases of osteosarcoma were cox-2 positive.The expression of cox-2 was related to the grade,but not related to the differentiation.Conclusion Cox-2 was related to the generation and prognosis,it may be an indicator for clinical diagnosis and prognosis evaluation of osteosarcoma and giant cell tumor of bone.
Key words:
Prostaglandin-endoperoxide synthase/ME; Osteosarcoma/ME; Giant cell tumor of bone/ME