2017•International journal of pediatricsRequires access
Clinical effect of bacterial lysates in the treatment of children with repeated respiratory infection
Yuna Chang, Liyun Liu, Jia Wang, Huisheng Yao, Lili Yi
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Abstract
Objective
To observe the efficacy of bacterial lysate(bronchovaxom) in the acute phase of respiratory tract infection and to prevent recurrent respiratory tract infections.
Methods
From April 2014 to April 2015, in pediatric respiratory ward of Shengjing hospital of China Medical University, 80 children with recurrent respiratory tract infection were randomly divided into treatment group and control group, with 40 cases in each group.The control group patients were received routine anti-infection and symptomatic treatment, the treatment group patients were received oral bacterial lysis products for 3 months on basis of the conventional anti-infection and symptomatic treatment.To observe the duration of clinical symptoms of two groups of children with respiratory tract infection in the acute phase, antibiotic use and hospital stay changes; observed the number of respiratory infections occurred again within 1 year; measured the levels of serum immunoglobulin before and 6 months after treatment.
Results
Compared with the control group, the duration of symptoms such as fever, cough and other symptoms of respiratory tract infection, the duration of pulmonary rales, the use of antibiotics and the length of hospital stay were significantly shortened in the treatment group, and the number of respiratory infections was significantly reduced, the difference significant(P<0.05). After treatment, the levels of IgG and IgA in the treatment group were significantly higher than those before treatment, and the immunoglobulin IgG and IgA in the treatment group were significantly higher than those in the control group(P<0.05).
Conclusion
Oral bacterial lysis products to prevent respiratory infections, not only can reduce the duration of various clinical symptoms of respiratory tract infection, shorten the use of antibiotics and hospital stay, and can improve children′s immunity, reduce the number of respiratory infections again.
Key words:
Children; Respiratory tract infections; Bacteria lysate; Immune globulin