Research on the correlation of COX-2 and renal cell carcinoma

Objective To explore the expression of Cyclooxygenase-2-specific(COX-2) in renal cell carcinoma and its relationship with angiogenesis.Methods The expression of COX-2,VEGF and bFGF in renal cell carcinoma specimens(85 cases) and adjacent normal tissue samples(48 cases) was measured by immunohistochemistry.Microvessel density (MVD) was evaluated by immunohistochemistry using a monoclonal antibody against CD34.Results The positive expression rates of COX-2,VEGF and bFGF in adjacent normal tissue were 16.7％,20.8％,22.9％,and 77.6％,80.0％,74.1％ in renal cell carcinoma,respectively,the difference,were significant ( all P ＜0.01 ).MVD was (55.47 + 18.47 ) Counts/field in renal cell carcinoma,and ( 20.42 ± 8.72) Counts/field in adjacent normal tissue,the difference was significant( P ＜ 0.01 ).MVD in renal cell carcinoma which was positive expressed COX-2,VEGF,bFGF was higher than renal cell carcinoma which was negative expressed COX-2,VEGF,bFGF,the difference was significantly statistical( P ＜ 0.05 or P ＜0.01 ).COX-2 expression and VEGF,bFGF in renal cell carcinoma expression was positively correlated( P ＜0.01 ).Conclusion COX-2 expression was elevated in renal cell carcinoma,and it was related closely with renal cell carcinoma angiogenesis. Key words: Renal tumor;  Cyclooxygenase-2-specific ;  Vascular endothelial growth factor;  Fibroblast growth factor;  Microvessel density