Anti-myelin oligodendrocyte glycoprotein antibody and central nervous system immune demyelinating diseases
Ji Zhou
Abstract
Ji Zhou
Abstract
Myelin oligodendrocyte glycoprotein(MOG) is a component of central nervous system myelin.Anti-MOG antibodies are important in both pediatric and adult demyelination and the clinical association of MOG antibody-induced demyelination has been refined to include neuromyelitis optica spectrum disease, optic neuritis, and acute disseminated encephalomyelitis.But there are still many questions about epidemiological, clinical, radiological, and prognostic profile in patients with MOG antibody-associated demyelination.No consensus has been reached on detecting this antibody.This review will summarize the advances in anti-Myelin oligodendrocyte glycoprotein antibody. Key words: Anti-Myelin oligodendrocyte glycoprotein antibody; Neuromyelitis optica spectrum disease; Acute disseminated encephalomyelitis
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Myelin oligodendrocyte glycoprotein(MOG) is a component of central nervous system myelin.Anti-MOG antibodies are important in both pediatric and adult demyelination and the clinical association of MOG antibody-induced demyelination has been refined to include neuromyelitis optica spectrum disease, optic neuritis, and acute disseminated encephalomyelitis.But there are still many questions about epidemiological, clinical, radiological, and prognostic profile in patients with MOG antibody-associated demyelination.No consensus has been reached on detecting this antibody.This review will summarize the advances in anti-Myelin oligodendrocyte glycoprotein antibody. Key words: Anti-Myelin oligodendrocyte glycoprotein antibody; Neuromyelitis optica spectrum disease; Acute disseminated encephalomyelitis
Key concepts: Myelin oligodendrocyte glycoprotein, Neuromyelitis optica, Acute disseminated encephalomyelitis, Multiple sclerosis, Medicine, Optic neuritis, Oligodendrocyte, Immunology