Evaluation of magnification chromoendoscopy combined with narrow-band imaging for diagnosis of neoplasia lesions of early gastric cancer

Objective To explore the clinical diagnostic value of narrow-band imaging combined with magnification chromoendoscopy for suspicious neoplasia lesions of early gastric cancer. Methods A total of 115 patients which had been diagnosed as having suspicious lesions by conventional endoscopy were enrolled from Jan. 2010 to Dec. 2012.They were observed by magnifying endoscopy(C-WLI), magnifying endoscopy combined with narrow-band imaging (ME-NBI), magnification chromoendoscopy and magnification chromoendoscopy combined with narrow-band imaging, respectively. The lesion outline sharpness, opening of the gland sharpness and microvascular morphology sharpness were recorded and the subtypes of opening of the gland and microvascular morphology were compared. The histological examination was performed on the most significant changes in lesion site and the accuracy, sensitivity and specificity of the four procedures were calculated. Results The score of outline sharpness was 377 and the score of pit sharpness was 458 by magnification chromoendoscopy combined with narrow-band imaging, higher than those of ME-NBI (340 and 408 respectively) and magnification chromoendoscopy (354 and 386 respectively) (P<0.05), significantly higher than those of C-WLI (276 and 280 respectively) (P<0.01). The score of microvascular morphology sharpness was 380 by magnification chromoendoscopy combined with narrow-band imaging, higher than that of ME-NBI(348, P<0.05), C-WLI (267, P<0.01) and magnification chromoendoscopy (280, P<0.01). The detection rate of C type by magnification chromoendoscopy combined with narrow-band imaging was higher than that by magnification chromoendoscopy (93.0% VS 79.7%, P<0.05). The accuracy, sensitivity and specificity of magnification chromoendoscopy combined with narrow-band imaging was 92.17%, 88.33%, 96.36% respectively. Conclusion Narrow-band imaging endoscopy combined with pigment amplification can yield more clear image of the microvascular morphology and opening of the gland, significantly improve the lesion detection rate, reduce the missing rate, and is worthy of further clinical observation and promotion. Key words: Precancerous lesion; Diagnosis; Narrow band imaging; Magnifying endoscopy