The curative effect of spasmolysis and anticoagulant therapy in early onset pre-eclampsia

Objective To analyze the curative effect and safety of spasmolysis and anticoagulant therapy in early onset pre-eclampsia.Methods One hundred and three patients with early onset pre-eclampsia at 26-34 weeks of gestational age were enrolled in this study,and they were divided into A group (magnesium sulfate treatment group,34 cases) and B group (magnesium sulfate + low molecular heparin treatment group,36 cases) and C group (magnesium sulfate + low molecular heparin + salvia miltiorrhiza treatment group,33 cases) by random digits table method.The coagulation function,24 h urine protein,pregnancy outcomes and neonatal situations were measured and compared among three groups.Results The coagulation function index and 24 h urine protein among three groups had no significant difference (P ＞ 0.05).The level of 24 h urine protein in A,B,C group prior to delivery was (5.38 ± 0.32),(4.96 ± 0.22) and (4.31 ± 0.26) g/24 h.The level of 24 h urine protein in A group was significantly higher than that in B group and C group (P＜ 0.05).The level of activated partial thromboplastin time(APTT) in A,B,C group was (31.45 ± 5.71),(33.34 ± 5.96) and (38.12 ± 3.49) s.The level of APTT in C group was significantly longer than that in A group and B group(P＜ 0.05).The level of other coagulation function index was no significant difference (P ＞ 0.05).The time of prolonged gestational age of A,B,C group was(6.40 ± 3.46),(10.70 ± 4.21) and (12.50 ± 3.73) d respectively,and there was no significant difference (P ＜ 0.05).The rate of complication among three groups had no significant difference (P ＞ 0.05).The body weight of neonate among three groups had no significant difference (P ＞ 0.05).The rate of neonatal asphyxia in A,B,C group was 29.4％ (10/34),19.4％ (7/36) and 6.1％ (2/33) respectively,and the rate of neonatal asphyxia in C group was significantly higher than that in A group and B group (P ＜ 0.05).The fatality rate of neonate among three groups had no significant difference (P ＞ 0.05).Conclusion Magnesium sulfate combined with low molecular heparin and salvia miltiorrhiza can control 24 h urine protein,improve the coagulation function,also can prolong the gestational age and improve neonatal prognosis of early onset pre-eclampsia. Key words: Pre-eclampsia;  Asphyxia neonatorum;  Magnesium sulfate;  Low molecular heparin;  Salvia miltiorrhiza