2002•Chin J Naut Med & Hyperbar MedRequires access

Combined therapy with hyperbaric oxygen and anti-platelet aggregation agent for the prevention of delayed encephalopathy after acute carbon monoxide poisoning

高春锦, 葛环, 赵立明, 武连华, 夏成青, Zhuo Li, 庞宝森, WANG Li

Abstract

目的观察高压氧(HBO)和抗血小板聚集剂综合疗法对一氧化碳中毒(COP)迟发脑病的预防效应.方法中、重度急性一氧化碳中毒患者共401例,随机分成HBO治疗组(HBO组)204例和HBO+抗血小板聚集剂治疗组(HBO+抗Pla组)197例.HBO治疗压力0.2 MPa,每日1次,共20次.在患者COP后第15,20,25,30,45,60天判定是否出现迟发脑病.结果 COP患者401例中,HBO组204例,出现迟发脑病23例,占11.27%.HBO+抗Pla组197例,出现迟发脑病7例,占3.55%.两组比较差异有非常显著性(P＜0.01).结论 HBO和抗血小板聚集剂综合治疗急性COP,使其迟发脑病的发生率较单纯HBO治疗明显降低,取得显著的预防效应.

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Key concepts: Carbon monoxide poisoning, Hyperbaric oxygen, CO poisoning, Medicine, Carbon monoxide, Oxygen, Encephalopathy, Anesthesia