2002•Chin J Naut Med & Hyperbar MedRequires access

An observation of the effect of hyperbaric oxygen increasing the sensitivity of leukemia cells to chemotherapy in vitro

谢晓平, 禹华玮, 尚振川, 周言新, 滕燕生

Abstract

目的观察体外白血病细胞在化疗药和高压氧(HBO)双重作用下对化疗敏感性的变化.方法将22例白血病患者的外周血每例分成4份,各归入以下4组:1. 用化疗药+HBO组;2. 单用化疗药组;3. 单用HBO组;4. 对照组(不加化疗药也不加HBO);统计各组血样的白血病细胞死亡比率.结果 1组与3组比较P＜0.0001;2组与4组比较P＜0.05;1组与2组比较P＜0.0001;3组与4组比较P＞0.05.结论肯定了化疗药对白血病细胞的杀伤作用,同时证明HBO加化疗药组与单用化疗药组或单用HBO组在体外白血病细胞杀死率差异非常显著,即HBO能提高体外白血病细胞对化疗药的敏感性,另外只用HBO不用化疗药对离体白血病细胞杀伤无任何意义.

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Key concepts: Leukemia, Chemotherapy, Sensitivity (control systems), In vitro, Medicine, Biology, Immunology, Internal medicine