2006•Zhongguo jiceng yiyaoRequires access

Clinical investigation of plasma adrenomedullin and C-type natriuretic peptide in the elderly hypertension

谭小颖, 陈树丹, 吕汉文

Abstract

目的研究老年高血压(HPE)患者血浆肾上腺髓质素(ADM)和C型利钠肽(CNP)的水平变化及其临床意义.方法放射免疫法测定136例HPE患者和40例健康老年人的血浆ADM、CNP水平,并进行对照统计分析.结果 HPE组总体血浆ADM、CNP水平显著高于健康对照组(均P＜0.01),HPE 1、2、3级组间血浆ADM、CNP水平依次显著性递增(均P＜0.01),且与高血压分级相平行(均P＜0.01);HPE伴靶器官损害(TOD)组血浆ADM、CNP水平显著高于无TOD组(均P＜0.01),且血浆ADM与CNP水平呈正相关(r＝0.63695,P＜0.01).结论 ADM、CNP可能共同参与了老年高血压的病理生理过程并在其中起代偿保护作用。

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Key concepts: Medicine, Adrenomedullin, Natriuretic peptide, Internal medicine, Endocrinology, Cardiology, Heart failure, Receptor