Comparison of the effects of nystatin suspension and fluconazole in the treatment of oropharyngeal candidosis

Objective To compare the efficacy of nystatin suspension and fluconazole in the treatment of oropharyngeal candidosis.Methods 40 patients were randomly assigned to nystatin suspension group or fluconazole group.Patients treated with nystatin suspension (n =20) were instructed to use 30ml of nystatin suspension for rinsing for 5 min,3 times daily.Patients treated with fluconazole(n =20) received capsules(150mg) each day.The clinical effect was assessed after treatment for 3 days.The recurrence was assessed 1 week after drug withdrawal.Results The effective rate in the nystatin suspension group and fluconazole group was 80.0％,85.0％,the recurrence rate in two groups was 18.8％,11.8％,respectively.There were no significant differences (all P ＞ 0.05).Conclusion Nystatin suspension is a good therapeutic alternative in the treatment of oropharyngeal candidosis. Key words: Oropharyngeal ;  Candidosis ;  Nystatin;  Fluconazole