2015•Zhonghua shiyan waike zazhiRequires access
Expression and significance of haptoglobin mRNA and protein in papillary thyroid carcinoma
Y. H. Fan, Yang Liu, Zheng Liu, Xiaoming Wang, Qingling Yuan, Xiubo Lu
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Abstract
Objective
To explore the expression and significance of haptoglobin(Hp)in papillary thyroid carcinoma.
Methods
Reverse transcriptase-polymerase chain reaction(RT-PCR) and Western blotting were applied to detect the expression of Hp in 112 cases of papillary thyroid carcinoma,67 cases of benign thyroid node and 50 cases of normal thyroid tissues.
Results
The relative expression value of Hp mRNA was(0. 913±0. 102)in papillary thyroid carcinoma tissues, which were over-expressed comparing with benign thyroid node(0. 357±0. 009)and normal thyroid tissue(0. 296±0. 008) groups(P 0. 05).In addition,although the level of Hp mRNA increased with the higher clinical stages, there were no statistical significance(P> 0. 05).
Conclusion
Our results suggested that Hp might play a key role in papillary thyroid carcinoma occurrence.Moreover, findings in the present study also provided evidence for the diagnostic and therapeutic strategies in the treatment of papillary thyroid carcinoma.
Key words:
Haptoglobin; Papillary thyroid carcinoma