The reproductive toxicity of NiKeAn in male rats

Objective To observe the toxic effects of NiKeAn on the ability of reproduction in male rats.Methods One hundred health adult Wistar rats were randomly divided into 4 groups with 25 in each group.The rats of control groups were given intravenous injections with normal saline and the experimental groups received NiKeAn at doses of 300 mg/kg,200 mg/kg and 100 mg/kg once per day.All rats were injected for 5 weeks then mated and executed.The coefficient of testicle and epididymis,mating rate,sperm,the percentage of motile sperm,and histopathological changes of testicle and epididymis were detected.Results Under doses of 200 mg/kg concentration of NiKeAn used in this study have no significant influence on the aforementioned parameters.Conclusion Under doses of 200 mg/kg,reproductive function of male rats does not obviously impaired by NiKeAn. Key words: Preconception injuries; Rats, Wistar; NiKeAn