Fertility and Embryotoxicity Study of Fengshiping Capsule in Rats

Objective:To study the toxic/disturbances of Fengshiping Capsule resulting from treatment from before mating(males/females) through mating and implantation in rats.Methods:The male SD rats were divided into 4 groups: Fengshiping Capsule(223 mg/kg,304 mg/kg,446 mg/kg,608 mg/kg) and negative group.The female rats were divided into 4 groups: Fengshiping Capsule(152 mg/kg,304 mg/kg,608 mg/kg,1216 mg/kg) and negative group.Within the 9 weeks before rats mate to mating succeeded,the male rats were administrated once a day.The female rats were administrated once a day from 2 weeks before mating to the 8th day of pregnancy.The male rats were dissected for examination of teratospermia and histopathology observation of testicle.The pregnancy rats were dissected at the 20th day after pregnancy.The corepus luteum,plant gland,absorbed fetus,live fetus,dead fetus,body weight were measured.Results:Spermatogenic cell dysplasia,oligozoospemia and teratospermia were found in male rats treated with Fengshiping Capsule(223 mg/kg,304 mg/kg,446 mg/kg,608 mg/kg).Brady-growth in body weight was found in female rats at the dose of 1216 mg/kg.The pregnancy rate of female rats was reduced at the dose of 304 mg/kg,446 mg/kg and 608 mg/kg.The amount of fetus lumbar and trail vertebra reduced at the dose of 608 mg/kg and 1216 mg/kg.Hypoevolutism were found in fetus skeleton at the dose of 1216 mg/kg.Conclusion: The results imply that Fengshiping Capsule can interfere Spermatogenic cell dysplasia,oligozoospemia and teratospermia in male rats.And it also influences the zygote implantation in female rats and skeleton hypoevolutism in fetus.