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2018•PubMedOpen access

The expression of MMP19 and its clinical significance in glioma.

Qisheng Luo, Hongcheng Luo, Xiaoping Chen, Peng Yan, Huangde Fu, Haineng Huang, Huadong Huang, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Qianli Tang

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Abstract

AIMS: The expression of phosphoglycerate kinase 1 (MMP19) is elevated in some cancers. However, the clinical features and prognostic value of glioma patients with MMP19 expression are unclear. In this study, the expression level of MMP19 and the correlation between the level of MMP19 expression and the clinicopathologic data in glioma patients including survival were examined. METHODS AND RESULTS: = 0.001). A Multivariate analysis indicated that a high expression of the MMP19 protein was an independent prognostic indicator of patient survival (P = 0.009). CONCLUSIONS: MMP19 is overexpressed and plays a significant role in disease progression and poor outcome in glioma patients.

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What this paper is about

AIMS: The expression of phosphoglycerate kinase 1 (MMP19) is elevated in some cancers. However, the clinical features and prognostic value of glioma patients with MMP19 expression are unclear. In this study, the expression level of MMP19 and the correlation between the level of MMP19 expression and the clinicopathologic data in glioma patients including survival were examined. METHODS AND RESULTS: = 0.001). A Multivariate analysis indicated that a high expression of the MMP19 protein was an independent prognostic indicator of patient survival (P = 0.009). CONCLUSIONS: MMP19 is overexpressed and plays a significant role in disease progression and poor outcome in glioma patients.

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Available abstract

AIMS: The expression of phosphoglycerate kinase 1 (MMP19) is elevated in some cancers. However, the clinical features and prognostic value of glioma patients with MMP19 expression are unclear. In this study, the expression level of MMP19 and the correlation between the level of MMP19 expression and the clinicopathologic data in glioma patients including survival were examined. METHODS AND RESULTS: = 0.001). A Multivariate analysis indicated that a high expression of the MMP19 protein was an independent prognostic indicator of patient survival (P = 0.009). CONCLUSIONS: MMP19 is overexpressed and plays a significant role in disease progression and poor outcome in glioma patients.

Key concepts: Glioma, Immunohistochemistry, Stage (stratigraphy), Clinical significance, Biology, Pathology, Messenger RNA, Protein expression

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