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2020•Journal of Emerging Technologies and Innovative ResearchRequires access

IN-VITRO EVALUATION OF SELECTED CHLORO-CHALCONES FOR ANTIOXIDANT ACTIVITY

Nagesh Deshmukh, S. R. Pingalkar, D. R. Munde, Yogesh S. Nalwar, Akruti Shinde

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Abstract

Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the ring. Were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity and OH radical scavenging activity. The synthetic chloro-substituted chalcones were found to be reactive towards DPPH radical and also possess good to moderate OH radical scavenging activity. These findings suggest that these chloro-substituted chalcones can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates.

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What this paper is about

Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the ring. Were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity and OH radical scavenging activity. The synthetic chloro-substituted chalcones were found to be reactive towards DPPH radical and also possess good to moderate OH radical scavenging activity. These findings suggest that these chloro-substituted chalcones can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates.

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Available abstract

Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the ring. Were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity and OH radical scavenging activity. The synthetic chloro-substituted chalcones were found to be reactive towards DPPH radical and also possess good to moderate OH radical scavenging activity. These findings suggest that these chloro-substituted chalcones can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates.

Key concepts: DPPH, Antioxidant, Chemistry, Hydrazine (antidepressant), Scavenging, Substituent, In vitro, Hydroxyl radical

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