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1982•Journal of AOAC INTERNATIONALRequires access

Spectrophotometric Determination of Menadione and Menadione Sodium Bisulfite

Madiha B. Sidhom, Michel E El-Kommos

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Abstract

Abstract A spectrophotometric method is described for the determination of menadione and menadione sodium bisulfite in bulk and in solution for injection. The method measures the intensity of the violet color (λmax 540 nm) developed when menadione reacts with thiosemicarbazide in alkaline medium. Beer's law is obeyed in the concentration range 4-40 μg/m L (r = 0.9995). The method is simple, sensitive, and particularly suited for routine analysis of official menadione sodium bisulfite injection. Results are comparable with the USP method.

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What this paper is about

Abstract A spectrophotometric method is described for the determination of menadione and menadione sodium bisulfite in bulk and in solution for injection. The method measures the intensity of the violet color (λmax 540 nm) developed when menadione reacts with thiosemicarbazide in alkaline medium. Beer's law is obeyed in the concentration range 4-40 μg/m L (r = 0.9995). The method is simple, sensitive, and particularly suited for routine analysis of official menadione sodium bisulfite injection. Results are comparable with the USP method.

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Available abstract

Abstract A spectrophotometric method is described for the determination of menadione and menadione sodium bisulfite in bulk and in solution for injection. The method measures the intensity of the violet color (λmax 540 nm) developed when menadione reacts with thiosemicarbazide in alkaline medium. Beer's law is obeyed in the concentration range 4-40 μg/m L (r = 0.9995). The method is simple, sensitive, and particularly suited for routine analysis of official menadione sodium bisulfite injection. Results are comparable with the USP method.

Key concepts: Menadione, Sodium bisulfite, Bisulfite, Chemistry, Chromatography, Sodium, Nuclear chemistry, Biochemistry

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