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2009•China Practical MedicineRequires access

HPLC Determination of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection

Zhang Ta

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Abstract

Objective To established a method to determine the contents of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection.Method Used an RP-HPLC method with SinoChromODS C18 column(200 mm×4.6 mm,5μm),the mobile phase was a mixture of 0.015 mol/L NaH2PO4 buffer solution-methanol(70:30),the flow rate was1.0 ml﹒min-1 and the detection wavelength was 230 nm.Results The calibration curve was linear in the range of 0.08～2.40 μg(r=0.9999).The average recovery was 99.8%(n=18).Conclusion The method is fast,simple and accurate,it can be used for the quality control of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection.

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What this paper is about

Objective To established a method to determine the contents of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection.Method Used an RP-HPLC method with SinoChromODS C18 column(200 mm×4.6 mm,5μm),the mobile phase was a mixture of 0.015 mol/L NaH2PO4 buffer solution-methanol(70:30),the flow rate was1.0 ml﹒min-1 and the detection wavelength was 230 nm.Results The calibration curve was linear in the range of 0.08～2.40 μg(r=0.9999).The average recovery was 99.8%(n=18).Conclusion The method is fast,simple and accurate,it can be used for the quality control of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection.

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Available abstract

Objective To established a method to determine the contents of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection.Method Used an RP-HPLC method with SinoChromODS C18 column(200 mm×4.6 mm,5μm),the mobile phase was a mixture of 0.015 mol/L NaH2PO4 buffer solution-methanol(70:30),the flow rate was1.0 ml﹒min-1 and the detection wavelength was 230 nm.Results The calibration curve was linear in the range of 0.08～2.40 μg(r=0.9999).The average recovery was 99.8%(n=18).Conclusion The method is fast,simple and accurate,it can be used for the quality control of Menadione Sodium Bisulfite in Menadione Sodium Bisulfite Injection.

Key concepts: Menadione, Sodium bisulfite, Bisulfite, Chromatography, High-performance liquid chromatography, Medicine, Sodium, Chemistry

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