Antibiogram of Clinical Isolates of Staphylococcus Aureus from a Tertiary Care Centre

Background: Staphylococcus aureus causes wide variety of infections. Methicillin resistant Staphylococcus aureus (MRSA) is of a great concern. It has developed resistance to non β-lactam antibiotics also and its treatment should be guided by antibiotic susceptibility testing. Aim: To study the antibiotic susceptibility pattern of clinical isolates of Staphylococcus aureus. Material & methods: A total of 300 clinical isolates of S. aureus were subjected to antimicrobial susceptibility testing by modified Kirby Bauer disc diffusion method as per the CLSI guidelines. MIC for vancomycin and linezolid was performed by agar dilution method. Results: Most of the strains of S. aureus were resistant to penicillin and methicillin resistance was as high as 35%. Resistance to non β-lactam antibiotics was found to be significantly more in MRSA strains as compared to methicillin sensitive S. aureus (MSSA). For prevention of increase in resistance, appropriate use of antibiotics guided by antibiotic sensitivity is necessary.