2020•Journal of VirologyOpen access

Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis

Megan E. Spurgeon, Paul F. Lambert

Abstract

Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.

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Key concepts: Biology, Pathogenesis, Human papillomavirus, Bovine papillomavirus, Virology, Transmission (telecommunications), Carcinogenesis, Papillomaviridae