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1996•International Journal of OncologyRequires access

Bovine papillomavirus type 4

Maria E. Jackson, Vincent O’Brien, Iain M. Morgan, Guillermo Grindlay, Maria Saveria Campo

Open publisher page 12 citations

Abstract

Papillomavirus induce benign tumours (papillomas) in a variety of animals. The papillomas generally regress but occassionally persist and may eventually progress to squamous cell carcinoma. One of the most extensively studies papillomaviruses is bovine papillomavirus type 4 (BPV4). BPV-4 induces papillomas of the upper alimentary canal which are at high risk of progressing to cancer in cattle eating bracken fern. In this review, several aspects of the biology of the virus are described and compared with other papillomavirus systems, including regulation of transcription of the viral oncogenes, function of the viral oncoproteins, cooperation between virus and chemical cofactors, and prophylactic and therapeutic vaccination programmes.

About this research paper

What this paper is about

Papillomavirus induce benign tumours (papillomas) in a variety of animals. The papillomas generally regress but occassionally persist and may eventually progress to squamous cell carcinoma. One of the most extensively studies papillomaviruses is bovine papillomavirus type 4 (BPV4). BPV-4 induces papillomas of the upper alimentary canal which are at high risk of progressing to cancer in cattle eating bracken fern. In this review, several aspects of the biology of the virus are described and compared with other papillomavirus systems, including regulation of transcription of the viral oncogenes, function of the viral oncoproteins, cooperation between virus and chemical cofactors, and prophylactic and therapeutic vaccination programmes.

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OpenAlex reports 12 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Papillomavirus induce benign tumours (papillomas) in a variety of animals. The papillomas generally regress but occassionally persist and may eventually progress to squamous cell carcinoma. One of the most extensively studies papillomaviruses is bovine papillomavirus type 4 (BPV4). BPV-4 induces papillomas of the upper alimentary canal which are at high risk of progressing to cancer in cattle eating bracken fern. In this review, several aspects of the biology of the virus are described and compared with other papillomavirus systems, including regulation of transcription of the viral oncogenes, function of the viral oncoproteins, cooperation between virus and chemical cofactors, and prophylactic and therapeutic vaccination programmes.

Key concepts: Bovine papillomavirus, Biology, Oncogene, Viral Oncogene, Papilloma, Virus, Papillomaviridae, Virology

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