Clinical Profile of the Patients with AntiphospholipidAntibodies: Lupus Anticoagulant and Anticardiolipin Antibodies

A retrospective analysis of clinical profile of the patients positive for antiphospholipidantibodies(150) thatarelupus anticoagulant (83) and anticardiolipin antibodies (57) was carried out fromJanuary 2015 toDecember2016inKasturba Medical College, Manipal. The diagnosis of lupus anticoagulants was basedonprolongationof dRVVT, its absence of correction with normal plasma and correction by phospholipids. The presenceof antiardiolipinantibodies was based on the technique ELISA (uolmmun). Out of 150 patients positive for antiphospholipidantibodies, the mean age of presentation was 38 years, more commonly seen in the women. Thefrequencyofthrombosis in patients positive forlupus anticoagulants was 55.5% (46), more commonly of venous originandinthelower limbs. The frequency of patients with lupus anticoagulants presenting with abortionwas 26(31.3%), immunethrombocytopenic purpura, was 80% (67), valvular heart disease was 5 (6%), 35 (42.1%) patients hadsecondaryLA due to autoimmune diseases like SLE, Sjogerns, APS. Anticardiolipin antibodies were present in57patients,more common in women. Thrombosis was seen in 28 (49%) patients, more of venous originandinthelowerlimbs. Other clinical manifestations were abortions seen in 8 (9%) patients, immune thrombocytopenic purpuraseenin18 (32.5%) patients, valvular heart diseases seen in 8 (14%) of the patients and autoimmune diseases seenin31.3%of the patients. Patients positive for both lupus anticoagulant and anticardiolipin antibodies (10) hadahigherrate of thrombosis around 60%, more commonly of venous origin and had higher associations withautoimmunediseases (80%).