2017•PubMedRequires access

[The expression of SnoN in human hypertrophic scar fibroblasts and the mechanism of its participation in hypertrophic scar formation].

Fei Li Kuang, Z Zhang, B Chen, C L Liu, Yu-ming Zhao, Zhishan Xu, X J Li

Abstract

The protein expression of SnoN in hypertrophic scar fibroblasts is reduced, which weakens its inhibitory effect on TGF-β(1) signal, thus amplifying the TGF-β(1) signal, and it may participate in the formation of hypertrophic scar.

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Key concepts: Hypertrophic scar, Fibroblast, Messenger RNA, Transforming growth factor, Blot, Reverse transcription polymerase chain reaction, Real-time polymerase chain reaction, Scar tissue