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Quantitative study on the expression of mRNA for TGF-β and collagenase (MMP-1),tissue metalloproteinase inhibitor-1(TIMP-1) in hypertrophic scar

Ji-Xiang Wu, PR Chin

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Abstract

Objective To investigate the expression of mRNA for TGF β,MMP\|1 and TIMP\|1 and their effects on the formation of hypertrophic scar (HTS). Methods In situ hybridization and image analysis were used in this study. Results The expressions of mRNA for TGF β and TIMP\|1 in HTS was greatly increased compared with those of normal skin. The average integral optical density of mRNA for TGF β and TIMP\|1 increased by 8 and 7 folds ( P 0.001) related to normal skin and the expression of them showed highly positive correlation.Conclusions The findings suggest that TGF β promotes the expression of TIMP\|1 and may be a possible factor for hypertrophic scar formation.

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What this paper is about

Objective To investigate the expression of mRNA for TGF β,MMP\|1 and TIMP\|1 and their effects on the formation of hypertrophic scar (HTS). Methods In situ hybridization and image analysis were used in this study. Results The expressions of mRNA for TGF β and TIMP\|1 in HTS was greatly increased compared with those of normal skin. The average integral optical density of mRNA for TGF β and TIMP\|1 increased by 8 and 7 folds ( P 0.001) related to normal skin and the expression of them showed highly positive correlation.Conclusions The findings suggest that TGF β promotes the expression of TIMP\|1 and may be a possible factor for hypertrophic scar formation.

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Available abstract

Objective To investigate the expression of mRNA for TGF β,MMP\|1 and TIMP\|1 and their effects on the formation of hypertrophic scar (HTS). Methods In situ hybridization and image analysis were used in this study. Results The expressions of mRNA for TGF β and TIMP\|1 in HTS was greatly increased compared with those of normal skin. The average integral optical density of mRNA for TGF β and TIMP\|1 increased by 8 and 7 folds ( P 0.001) related to normal skin and the expression of them showed highly positive correlation.Conclusions The findings suggest that TGF β promotes the expression of TIMP\|1 and may be a possible factor for hypertrophic scar formation.

Key concepts: Collagenase, In situ hybridization, Hypertrophic scar, Messenger RNA, Matrix metalloproteinase, Transforming growth factor, Tissue inhibitor of metalloproteinase, Interstitial collagenase

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Quantitative study on the expression of mRNA for TGF-β and collagenase (MMP-1),tissue metalloproteinase inhibitor-1(TIMP-1) in hypertrophic scar — Research Paper | ScholarLens