Expression of Hypoxia Inducible Factor lα and Its Significance in Non-small Cell Lung Cancer

Objective: To explore the expression level and its clinical significance of hypoxia inducible factorlα (HIF-lα) in non-small lung cancer. Methods: The expression of HIF-lα was detected in 68 humannon-small lung cancer samples by immunohistochemistry. Results: (1) Thirty-nine (57.35%) out of the 68human non-small lung cancer samples was positive for HIF-lα; (2) The positive rate of HIF-lα in adeno-carcinoma and squamous carcinoma was 54.76% (23/42) and 61.54% (16/26) respectively. No significantdifference was found between adenocarcinoma and squamous carcinoma of non-small lung cancer in theexpression of HIF-lα (P0.05). The positive rate of HIF-lα in middle-high differentiation was 74.28%(26/35), significantly higher than in low differentiation (39.39%, 13/33) (P0.05); (3) The positive expres-sion of HIF-lα was not correlated to the sexes, ages, tumor stage and lymph node status. Conclusion:The expression of HIF-lα is higher in non-small lung cancer and is correlated to differentiation.