Expression and significance of HIF-1α and P300/CBP in squamous cell carcinoma and adenocarcinoma of lung

Objective:To investigate the expression of HIF-1α and P300/CBP in non-small cell lung cancer and to find out their correlation with histological type,cell differentiation,metastasis of squamous cell carcinoma and adenocarcinoma of lung.Methods:The expression of HIF-1α and P300/CBP was detected in 60 NSCLC tissues by highsensitive S-P immunohistochemical method.Results:The abnormal expression rate of HIF-1α was 48.33% in cancer tissues.Expression of HIF-1α protein was detected in a significantly greater proportion in squamous cell carcinoma and adenocarcinoma of lung than that in normal bronchial epithelium(P 0.01);There was no relationship between HIF-1α expression and age or sex;otherwise,there was closely relationship between HIF-1α expression and cellular differentiation,lymph node metastases and smoking;Expression of HIF-1α was negatively correlated with expression of P300/CBP(P 0.01).Conclusion:Expression of HIF-1α protein reduced the protein level of P300/CBP,indicating HIF-1α plays an important role in oncogenesis and development of lung cacncer.