2016•PubMedRequires access
ANALGESIC, ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF GREWIA ASIATICA FRUIT EXTRACTS IN ALBINO MICE.
Bushra Akhtar, Muhammad Ashraf, Aqeel Javeed, Ali Sharif, Muhammad Furqan Akhtar, Ammara Saleem, Irfan Hamid, Sadia Alvi, Ghulam Murtaza
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Abstract
The present study was aimed to assess biological (analgesic, antipyretic and anti-inflammatory) activities of methanolic and aqueous fruit extracts of Grewia asiatica. The study was performed on albino mice. Analgesic effect of the extracts was determined by acetic acid induced writhing. Antipyretic potential of the tested fruit extracts was assessed by brewer's yeast induced pyrexia. Carrageenan induced paw edema method was used to evaluate the anti-inflammatory activity. Both the extracts showed biological effects in a dose dependent fashion at doses 125 mg/kg, 250 mg/kg and 500 mg/kg orally. Analysis of variance (ANOVA) was used for data analysis and the values having p-value smaller than 0.05 were considered significant. Both the extracts had significant analgesic, antipyretic and anti-inflammatory activities.