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2019•bioRxiv (Cold Spring Harbor Laboratory)Open access

NorK, a novel norfloxacin efflux pump in Staphylococcus aureus

Paul Briaud, Jessica Baude, Sylvère Bastien, Laura Camus, François Vandenesch, Karen Moreau

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Abstract

Abstract A novel efflux pump similar to Nor efflux pumps and designated as NorK was identified in Staphylococcus aureus . It contributes to norfloxacin resistance and presents a high level of expression in different strains. Its expression is not regulated by MgrA, unlike other genes of the nor gene family, suggesting that NorK could be important in the absence of expression of other nor genes.

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Abstract A novel efflux pump similar to Nor efflux pumps and designated as NorK was identified in Staphylococcus aureus . It contributes to norfloxacin resistance and presents a high level of expression in different strains. Its expression is not regulated by MgrA, unlike other genes of the nor gene family, suggesting that NorK could be important in the absence of expression of other nor genes.

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Available abstract

Abstract A novel efflux pump similar to Nor efflux pumps and designated as NorK was identified in Staphylococcus aureus . It contributes to norfloxacin resistance and presents a high level of expression in different strains. Its expression is not regulated by MgrA, unlike other genes of the nor gene family, suggesting that NorK could be important in the absence of expression of other nor genes.

Key concepts: Efflux, Norfloxacin, Staphylococcus aureus, Microbiology, Gene, Gene expression, Biology, Antibiotics

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