2019•PubMedRequires access
[The analysis of peripheral blood T lymphocyte subsets in patients with colorectal cancer: a single center cross-section study].
Tong-Xin Xiao, G N Zhang, Zhuolin Qiu, Chao Xing, Tianhua Li
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Abstract
The distribution of peripheral blood lymphocyte subsets were compared between patients with colorectal cancer and healthy controls. The number of natural killer(NK) cells and CD(8)(+)T cells and the percentage of naive CD(4)(+) T cells were all decreased significantly in patients. On the contrary, the percentages of memory CD(4)(+) T cells, HLA-DR(+) CD(8)(+) T cells and CD(38)(+) CD(8)(+) T cells were significantly increased. It suggests that the tumor killing effect of cytotoxic lymphocytes in peripheral blood is impaired in patients with colorectal cancer, whereas the immune response is over stimulated.