2017•PubMedRequires access

[The effect of captopril and losartan on paraquat-induced pulmonary fibrosis and PlGF expression in the lungs of rats].

Min Zheng, Mu-sen Dai, Lifang Lin

Abstract

PlGF may plays an important role in the development of pulmonary fibrosis following paraquat-induced lung injury in rats. Captopril and losartan had an inhibitory effect on paraquat-induced pulmonary fibrosis, and the effect may be due to inhibition of angiotensin II and, in part, be associated with reduction in PlGF.

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Key concepts: Losartan, Captopril, Pulmonary fibrosis, Medicine, Hydroxyproline, Paraquat, Lung, Saline