2017•PubMedRequires access

[Therapeutic effects of Chai Qin Cheng Qi decoction on severe acute pancreatitis complicated liver damage in rats and its mechanisms].

Dang Lin, Xiaoqin Zhang, Fang Liu, Xiaofan Xu, Fangfang Li, Wei Xu, Hong Zhang

Abstract

OBJECTIVE: To study the effects of Chai Qin Cheng Qi Decoction(CQCQD)(Traditional Chinese Medicine)on severe acute pancreatitis (SAP)complicated liver damage in rats. METHODS: =24):Sham group, SAP group and CQCQD treatment group. SAP model was induced by retrograde injection with sodium taurocholate. The rats in CQCQD group received treatment with CQCQD. After modeling 1 h, 5 h, 10 h, pancreas and liver histopathological changes were observed. The serum levels of interleukin-6(IL-6), amylase(AMS), alanine aminotransferase(ALT) and aspartate transaminase(AST) were detected. IL-6 and monocyte chemotactic protein 1(MCP-1)mRNA in pancreas and liver were assayed. RESULTS: <0.05). CONCLUSIONS: MCP-1 takes part in the progression of SAP complicated liver damage; CQCQD can significantly inhibit the expression of pancreas and liver MCP-1, alleviate pathological damage of pancreas and liver in SAP and play a therapeutic role in SAP complicated liver damage.

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Key concepts: Medicine, Decoction, Internal medicine, Acute pancreatitis, Pancreas, Pancreatitis, Gastroenterology, Alanine transaminase