2013•Zhongguo kangfu lilun yu shijianRequires access
Anti-oxidative Stress Effect of Lycopene on Motor Function after Spinal Cord Injury in Rats
Yang Zheng
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Abstract
Objective To observe the influence of anti-oxidative stress effect of lycopene(LP) on motor function after spinal cord injury(SCI) in rats.Methods 36 healthy adult Sprague-Dawley rats were randomly divided into Groups A,B and C with 12 rats in each group.SCI model was made by Allen's mode(10 g×25 mm) on T9.Group A received no treatment,30 mg/kg methylprednisolone sodium succinate was injected for Group B in peritoneal cavity 30 min after SCI,20 mg/kg LP was given orally for Group C.On the 1st d,3rd d and 7th d after operation,the motor function was assessed by slanting board test and Basso-Beattie-Bresnahan scale(BBB);superoxide dismutase(SOD) and malondialdehyde(MDA) were determined in serum.Results Compared with Group A,the scores of the slanting board test significantly increased in Group C 1 d,3 d,and in Group B 1 d,3 d and 7 d after operation(P0.05);the BBB scores significantly increased in Group C 1 d,3 d and 7 d,and in Group B 1 d,7 d after operation(P0.05);the activity of SOD significantly increased in Group C 1 d,3 d and 7 d,and in Group B 3 d,7 d after operation(P0.05);the content of MDA significantly decreased in Group C 3 d,7 d,and in Group B 1 d,7 d after operation(P0.05).Conclusion Lycopene can reduce the level of oxidative stress and promote the motor function in rats after acute SCI.