2012•Zhongguo kangfu lilun yu shijianRequires access
Effect of Proanthocyanidin on Motor after Spinal Cord Injury in Rats
Du Gong
Open publisher page 0 citations
Abstract
Objective To observe the effect of Proanthocyanidin on motor after spinal cord injury(SCI) in rats.Methods 36 healthy adult SD rats were divided into groups A,B and C(n=12),and SCI was induced with Allen's mode(250 g·mm) on T9.Proanthocyanidin 40 mg/kg was injected intraperitoneally for group A,methylprednisolone(MP) 30 mg/kg for group B and the same volume of saline for group C 30 min after SCI.1 d,3 d and 7 d after operation,all the rats were assessed with Basso-Beattie-Bresnahan(BBB) scale and slanting board test,and their serumal malondialdehyde(MDA) and superoxide dismutase(SOD) were detected.Results The scores of BBB and the slanting board test imporoved more in group A and group B than in group C(P0.05).The SOD increased and MDA decreased in groups A and B significantly 1 d and 3 d after operation compared with those of group C(P0.05),and only in group A 7 d after operation(P0.05).Conclusion Proanthocyanidin may inhibit the lipid peroxidation and promote the recovery of motor after spinal cord injury in rats.