2008•Shandong yiyaoRequires access
Effect of Dauricine on the contents of MDA and the activities of SOD of the serum during myocardial ischemia reperfusion in rabbits
Lei Zhang
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Abstract
Objective To explore the effect of Dauricine(Dau) on the contents of MDA and the activities of SOD of the serum during myocardial ischemia reperfusion in rabbits.Methods 24 rabbits were randomly divided into three groups:the control group(n = 8),ischemia reperfusion(IR) group(n = 8),ischemia reperfusion(IR) + Dau intervention group(n = 8).Left anterior descending coronary artery was ligated to establish the model of myocardial reperfusion injury in rabbits.At 40 minutes after ischemia,the ligation was released to restore blood reperfusion.Evaluate and compare the change of the contents of MDA and the activities of SOD of rabbits serum before and after ischemia and at different times of reperfusion.Results At 40 minutes after ischemia,the content of MDA in rabbits serum was beginning to increase significantly and the activity of SOD was reduced significantly(both P0.05) compared to the control group.In IR + Dau (amount of 3.5 mg/kg)intervention group,at 40 minutes after ischemia and the times after reperfusion the corresponding contents of MDA were reduced significantly and the corresponding activities of SOD were increased significantly in rabbits serum compared to the IR group.Conclusion Dau could attenuate the injury induced by lipid peroxidation and enhance the activity of SOD,thus it plays a protective role in myocardial reperfusion injury in rabbits.