75 Patients with Chronic Hepatitis B Treated with Compound Zhenzhuchongcao Capsules

Objective:To survey the curative effect of compound zhenzhuchongcao capsules in the treatment of chronic hepatitis B associated with liver fibrosis. Methods:124 patients with chronic hepatitis B were randomly divided into two groups. 75 patients of the treatment group were given each 4 capsules of compound zhenzhuchongcao b.i.d. PO while 49 patients of the control group were treated t.i.d. with yiganning to be taken after being infused in boiling water. The course of treatment in both groups lasted 6 mon. Changes in the pathological histology of the liver and the 4 serum indices reflecting hepatic fibrosis were kept under observation. Results:The rates of dramatic improvement in clinical symptoms and serum ALT normalization in the treatment group were 64.3% and 91.0%, respectively, while those in the control group were 34.2% and 20.1%( P 0.05), respectively. The levels of the 4 serum indices in the treatment group were significantly lowered( P 0.01), while those in the control group showed no evident improvement( P 0.05). As to the pathologic histology of the liver, striking amelioration in inflammation and fibrosis ( P 0.05, P 0.01) was demonstrated in the treatment group, while no apparent inprovement was shown in the control group. Conclusion:Compound zhenzhuchongcao capsules were shown to be fairly effective in improving clinical symptoms and mitigating hepatic fibrosis in patients with chronic hepatitis B.