2005•Yiyao daobaoRequires access
Effect of Compound Fetal Bovine Liver Extract Tablets in Combination with Lamivudine on Hepatic Fibrosis in Patients with Chronic Hepatitis B
Lao Guo-qin, Yong Wu, Jialiang Wang
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Abstract
Objective To study the effect of compound fetal bovine liver extract tablets in combination with lamivudine on hepatic fibrosis in patients with chronic hepatitis B. Methods 174 patients with chronic hepatitis B were randomly divided into 3 groups: the control group(n=56),positive control group(n=58) and treatment group (n=60).Patients of the control group were submitted to a 6 month treatment course with oral medication of 2 Fructus silybi tablets and drugs for symptomatic treatment . On the basis of the treatment for patients of the control group, patients of the positive control group were given each additionally 100 mg of lamivudine q.d. PO for at least one year. Based on the treatment for patients of the positive control group, patients of the treatment group were given each 2 tablets of compound fetal bovine liver extract PO t.i.d. for 6 months. Serum levels of hyaluronidase (HA), type Ⅲ procollagen (PCⅢ), laminin(LN), type Ⅳ collagen (Ⅳ-C) were determined with radioimmunoassay (RIA)in patients of all 3 groups before and 3 as well as 6 months after the beginning of the treatment. The internal diameter of the trunk of the portal vein, the average speed and volume of blood flow in the portal vein and the thickness of the spleen were examined with color Doppler. Light microscopic examination of the liver pathohistology was carried out in 60 patients before and 6 months after the beginning of treatment. Results After 6 months of treatment, levels of serum PCⅢ,HA,LN and Ⅳ-C in patients of the positive control group and treatment group were notably lower than those in patients of the control group(P0.01), and these hepatic fibrosis indexes were also significantly lower in patients of the treatment group than those in patients of the positive control group(P0.01). Situations of the internal diameter of the trunk of the portal vein, the speed and volume of the blood flow in the portal vein and the thickness of the spleen were strikingly improved in patients of the positive control group and treatment group as compared with those of the control group(P0.01 or P0.05).Among these, the extent of improvement in the internal diameter of the trunk of the portal vein and the thickness of the spleen was greater in patients of the treatment group than that in patients of the control group(P0.05 or P0.01). Striking improvement in the scoring of the activity of the liver inflammation and the extent of hepatic fibrosis was demonstrated in patients of the positive control and treatment group as compared with that in patients of the control group(P0.01). The improvement in these parameters, however, was more significant in patients of treatment group than in patients of the positive control group(P(0.01)). Conclusion It was shown that compound fetal bovine liver extract tablets in combination with lamivudine exerted a definite therapeutic effect in the treatment of chronic hepatitis B with hepatic fibrosis.