2008•Huaxi yixueRequires access
IGFBP-2 mRNA Expression in Gastric Cancer Tissues and Its Roles in Lymph Node Metastasis of Gastric Cancer
Mingming Zhang
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Abstract
Objective:To detect the expression of IGFBP-2 mRNA in gastric cancer tissues and its roles in neoplasia and lymph node metastasis of gastric cancer.Methods:The IGFBP-2 mRNA expression levels in the fresh tissues from normal mucosa,primary cancer and lymph node metastasis of 35 patients with gastric cancer were determined by the Quantitative Real Time RT-PCR method,and the samples were sliced up and stained with hematoxylin-eosin for pathologyical examination.Results:The levels of IGFBP-2 mRNA expression in gastric primary cancer tissues were significantly higher than those in the tissues from normal mucosa and lymph node metastasis(P0.05).Yet,IGFBP-2 mRNA expression levels showed no difference between the tissues of normal mucosa and lymph node metastasis(P0.05).Conclusion:The expression of IGFBP-2mRNA possibly plays an important role in proliferation and lymph node metastasis of gastric cancer,and it might be useful in a new approach for clinical prognostication and treatment of gastric cancer lymph node metastasis.