Study of medical sodium hyaluronate gel in the prevention of postoperative adhesions in gynecological tumor

Objective To study the clinical effect of medical sodium hyaluronate gel in the prevention of postoperative adhesions in gynecological tumor. Methods 120 patients with gynecological tumor undergone surgery in our hospital from May 2013 to April 2014 were selected as research objects,and they were randomly and evenly divided into control group(routine operation treatment) and observation group(on the basis of routine operation treatment adding medical sodium hyaluronate gel),the incidence rate of postoperative adhesions and related indexes of peritoneal fluid adhesion before and after treatment between two groups were compared. Results The incidence rate of adhesion in patients undergone laparoscopic surgery in control group(10.00%) and incidence rate of adhesion in patients undergone laparotomy(15.00%) much higher than those in observation group(0 and 2.50% respectively) with statistical difference(P0.05).After 3 days treatment,indexes of hyaluronic acid(HA),laminin(LN),tumor growth factor-β1(TGF-β1) and fibronectin(Fn) in control group [(35.83 ±3.54) μg/L,(33.34±2.69) ng/ml,(72.17 ±8.95) μg/L and(13.57 ±1.68) ng/ml respectively] was remarkably higher than that in control group [(28.52±3.10) μg/L,(22.37±2.38) ng/ml,(58.36±7.18) μg/L and(8.92±1.2) ng/ml respectively] respectively,the difference was significant(P0.05).After 7 days treatment,indexes of HA,LN,TGF-β1and Fn [(30.15±3.26) μg/L,(25.60±2.41) ng/ml,(60.33±7.26) μg/L and(10.25±1.33) ng/ml reapectively]in control group was obviously higher than that in observation group[(23.21±2.87) μg/L,(17.42±2.24) ng/ml,(45.29±6.37) μg/L and(7.05±0.73) ng/ml respectively] respectively,and the difference was significant(P0.05). Conclusion Medical sodium hyaluronate gel obtains a good clinical effect in preventing postoperative adhesions in gynecological tumor and plays a positive role in patient′s rehabilitation after surgery.