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2011•Chinese Journal of Hospital PharmacyRequires access

Study on analgesic effect of Bilestone 6th Decoction and its influence on liver function

Tian Ying-biao

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Abstract

OBJECTIVE To study the analgesic effect of Bilestone 6th Decoction and its influence on liver function.METHODS The mice were divided into saline control group,positive control group,gallstones on Bilestone 6th Decoction of high,medium and low dose groups.By using the chemical stimulation to observe the analgesic effect of decoction of Bilestone 6th Decoction;and using mice eye blood,the blood biochemical indexes were observed.RESULTS The data showed that Bilestone 6th Decoction significantly attenuated writhing induced by acetic acid.Meanwhile,Bilestone 6th Decoction decreased alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activities,but increased total protein(TP) in serum in mice.However,Bilestone 6th Decoction did not affect albumin(ALB) and globulin(GLO) levels.CONCLUSION Bilestone 6th Decoction may own analgesic effect,and have liver-protective potential effect.

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OBJECTIVE To study the analgesic effect of Bilestone 6th Decoction and its influence on liver function.METHODS The mice were divided into saline control group,positive control group,gallstones on Bilestone 6th Decoction of high,medium and low dose groups.By using the chemical stimulation to observe the analgesic effect of decoction of Bilestone 6th Decoction;and using mice eye blood,the blood biochemical indexes were observed.RESULTS The data showed that Bilestone 6th Decoction significantly attenuated writhing induced by acetic acid.Meanwhile,Bilestone 6th Decoction decreased alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activities,but increased total protein(TP) in serum in mice.However,Bilestone 6th Decoction did not affect albumin(ALB) and globulin(GLO) levels.CONCLUSION Bilestone 6th Decoction may own analgesic effect,and have liver-protective potential effect.

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Available abstract

OBJECTIVE To study the analgesic effect of Bilestone 6th Decoction and its influence on liver function.METHODS The mice were divided into saline control group,positive control group,gallstones on Bilestone 6th Decoction of high,medium and low dose groups.By using the chemical stimulation to observe the analgesic effect of decoction of Bilestone 6th Decoction;and using mice eye blood,the blood biochemical indexes were observed.RESULTS The data showed that Bilestone 6th Decoction significantly attenuated writhing induced by acetic acid.Meanwhile,Bilestone 6th Decoction decreased alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activities,but increased total protein(TP) in serum in mice.However,Bilestone 6th Decoction did not affect albumin(ALB) and globulin(GLO) levels.CONCLUSION Bilestone 6th Decoction may own analgesic effect,and have liver-protective potential effect.

Key concepts: Decoction, Analgesic, Albumin, Liver function, Pharmacology, Medicine, Stimulation, Saline

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