Relation and Value of ThinPrep Cytological Test and High Risk Hybrid Capture 2 Human Papilllmavirus DNA Test in Cervical Lesions Screening

Objective To study the relation and value of ThinPrep cytological test(TCT)and high risk hybrid capture 2human papillomavirus(HC2-HPV)DNA test in screening of cervical lesions. Methods Four hundred and fifty-one patients who simultaneously underwent ThinPrep cytology test and HC2-HPV DNA test in Hunan Provincial Maternal and Child Health Hospital from May to July 2012 were enrolled in this study.Colposcopy examination was conducted in the patients with one positive result of the above-mentioned tests or with suspected clinical symptoms,and the colposcopic diagnosis results were compared and analyzed so as to explore the relation and application value of TCT and HC2-HPV DNA test. Results Among451 patients,254(56.3%)had an abnormal result of TCT.ASCUS,LSIL,HSIL and SCC were seen in 96(21.2%),75(16.6%),57(12.6%),and 26(5.7%)patients,respectively.Among 254 women with abnormal TCT result,the positive rate of high risk HPV was 68.1%.The high risk HPV positive rates of ASCUS,LSIL,HSIL,and SCC were 42.7%(41/96),76.0%(57/75),85.9%(49/57)and 100%(26/26),respectively.It showed that with the increase of cervical lesions degree,HPV infection rate also increased accordingly. Conclusions The results suggest that TCT combined with HC2-HPV DNA test is an effective method in detection and diagnosis of cervical cancer and precancerous lesions,which improves the accuracy rate of diagnosis and reduces the omission diagnostic rate.It is the best cervical screening test at present and provides a more reliable scientific basis for prevention and treatment of cervical lesions.