Research on nosocomial infection and drug resistance of Pseudomonas aeruginosa

Objective To investigate the distribution and drug resistance state of Pseudomonas aeruginosa,so as to offer reasonable experimental data for clinical therapy.Methods A statistic analysis for the specimen source,distribution of infected departments and drug resistance state to 441 isolates was conducted in a retrospective way.Results Among 441 strains,357(80.95%)were isolated from sputum species.The department with the highest isolating rate was ICU(26.5%),followed by department of respiratory disease(20.63%),department of neurosurgery(19.05%)and department of geriatrics(17.01%).The most sensitive antibiotic was Meropenem,which total drug resistance rate was 13.61%;the most insensitive antibiotic was ampicillin-sulbactam,which total drug resistance rate was 91.38%.The drug resistance rate of P.aeruginosa was increasing year by year.Conclusion Clinical isolates of P.aeruginosa mostly come from sputum samples and ICU,and they are highly and multidrug resistant to various antibiotics.