Drug Resistance of Pseudomonas Aeruginosa Strains in ICU

Objective To investigate the clinical distribution and drug resistance of P.aeruginosa infection in the ICU of our hospital and provide basis for rational drug therapy.Methods Samples isolated from ICU between July 2008 and October 2009 were carried out routine culture and identification for pathogenic bacteria.And drug sensitivity test was performed.Clinical distribution and drug resistance of P.aeruginosa were obtained by statistical analysis.Results 101 P.aeruginosa strains were derived from clinical specimens,and most isolated from sputum samples accounting for 65(64. 3%).Drug resistant rate of P.aeruginosa to ampicillin was the highest(98%),to meropenem was lower(33.7%),to polymyxin E was the lowest(8.9%).And resistance to other antimicrobial agents varied.Conclusions The rate of P. aeruginosa infection in ICU is highly prominent,and its drug resistance and multiple drug resistance are serious.Antimicrobial treatment to P.aeruginosa infection should be guided by drug sensitivity test.