Effect of Neural Stem Cell on Behavior and Histological Changes of Rats after Spinal Cord Injury

Objective To observe the effect of neural stem cells on the behavior and histological changes of rats after acute spinal cord injury.Methods The model of spinal cord injury was established and neural stem cells were injected into the spinal cords of rats.The behavior and histological changes were observed by H-E and Nissl staining.Results In behavior examination,there was significant difference(P0.05) between the spinal cord injury group treated with stem cells and the spinal cord injury control group.In histological examination,there were small splinter haemorrhage in the gray matter and white matter.The degree of axonal swelling,fragmentation of myelin sheath,and the damage of nerve cell of the treatment group were lower than those of the spinal cord injury control group while there were more glia cells in the zone of injury of the treatment group than in that of the spinal cord injury control group(P0.05).Conclusion The application of neural stem cells can lower the degree of axonal swelling,fragmentation of myelin sheath and the damage of nerve cell,thus reducing the degree of spinal cord injury and promoting the proliferation of glia cells in the injury zone and finally repairing the spinal cord.The transplanted neural stem cells can restore the feeling and motor function to the rats with spinal cord injury.