2019•Natural Product CommunicationsOpen access
Studies toward the Total Synthesis of Epothilone D: Synthesis of the Thiazole-Containing Northern Segment
Momoko Suzuki, Shougo Hashimoto, Shun Sakamoto, Hiroshi Kogen, Kenichi Kobayashi
Open full text 0 citations
Abstract
Epothilone D, a microtubule-stabilizing macrolide, is an attractive synthetic target molecule as a potential anti-cancer drug candidate. As part of our ongoing synthetic studies of this natural product, this paper describes the synthesis of the thiazole-containing northern segment of epothilone D via an E-selective bromomethylenation and a Ni/Cr-mediated cross-coupling reaction.
Open-access reader