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2011•World Clinical DrugsRequires access

Research progress of epothilone B,D and their derivatives

Haifeng Hu

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Abstract

Epothilones are natural macrolides targeting microtubule.The epothilones which have been or are being developed are aza-epothilone B,epothilone D,epothilone B,epothilone F,epothilone A.Aza-epothilone D has high potential to become an effective candidate of antitumor agent.From the structure and mechanism,this review summarizes the research progress of epothilone B,D and their derivatives.

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What this paper is about

Epothilones are natural macrolides targeting microtubule.The epothilones which have been or are being developed are aza-epothilone B,epothilone D,epothilone B,epothilone F,epothilone A.Aza-epothilone D has high potential to become an effective candidate of antitumor agent.From the structure and mechanism,this review summarizes the research progress of epothilone B,D and their derivatives.

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Available abstract

Epothilones are natural macrolides targeting microtubule.The epothilones which have been or are being developed are aza-epothilone B,epothilone D,epothilone B,epothilone F,epothilone A.Aza-epothilone D has high potential to become an effective candidate of antitumor agent.From the structure and mechanism,this review summarizes the research progress of epothilone B,D and their derivatives.

Key concepts: Epothilones, Epothilone, Ixabepilone, Medicine, Pharmacology, Stereochemistry, Internal medicine, Chemistry

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