Michael A. Abramov, Suzanne Toppet, Wim Dehaen
Abstract
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5,6,7,8-Tetrafluoro-1,2-azolo[3,4- b;4′,3′- e]quinolines react regiospecifically with aliphatic and aromatic amines, alcohols and phenols yielding 7-substituted 5,6,8-trifluoro-1,2-azolo[3,4- b;4′,3′- e]quinolines.
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5,6,7,8-Tetrafluoro-1,2-azolo[3,4- b;4′,3′- e]quinolines react regiospecifically with aliphatic and aromatic amines, alcohols and phenols yielding 7-substituted 5,6,8-trifluoro-1,2-azolo[3,4- b;4′,3′- e]quinolines.
Key concepts: Nucleophile, Fluorine, Nucleophilic substitution, Chemistry, Substitution reaction, Substitution (logic), Nucleophilic aromatic substitution, Medicinal chemistry