1998•Australian Journal of ChemistryRequires access

Terpene Metabolites from the Tropical Marine Sponge Axinyssa sp. nov.

Jamie S. Simpson, Mary J. Garson, John N. A. Hooper, Edith I. Cline, Cindy K. Angerhofer

Abstract

A new sesquiterpene isothiocyanate, ( – )-9-isothiocyanatopupukeanane (4), has been isolated along with the known sesquiterpene metabolites ( – )-9-isocyanopupukeanane (1), ( – )-2-thiocyanatoneopupukeanane (2) and ( – )-epipolasin-A (3) from the sponge Axinyssa sp. nov. Metabolites (1), (2) and (4) showed modest in vitro antimalarial activity.

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Key concepts: Sponge, Sesquiterpene, Isothiocyanate, Terpene, Tropical marine climate, Biocatalysis, Botany, Chemistry